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Cartherics and TiCARos collaborate to lead advancement of CLIP-CAR technology

Cartherics, a leading allogeneic NK cell platform developer, has entered into a collaboration with TiCARos, a company specializing in developing CAR-T cell products for cancer treatment. The collaboration aims to generate CLIP-CAR constructs that will be incorporated into Cartherics’ NK cells for assessing their function both in vitro and in vivo.

The CLIP-CAR approach developed by TiCARos modifies the CAR structure to stabilize the immune synapse between immune cells and target tumor cells, resulting in improved efficacy in models. By combining TiCARos’ CLIP-CAR technology with Cartherics’ allogeneic NK cell platform, the two companies aim to enhance the effectiveness of cancer therapies.

Professor Alan Trounson, CEO of Cartherics, believes that this collaboration has great potential. He believes that by collaborating with innovative companies like TiCARos, Cartherics can build a leading portfolio of therapeutic products for cancer treatment. The collaboration between the two companies aims to develop a CAR-NK product targeting tissue factor (TF) for triple negative breast cancer and other challenging cancers.

Each company has nominated a specific tumor antigen to target with the CARs. Cartherics is focusing on TF while TiCARos is targeting CD19. This collaboration aims to accelerate pipeline programs and expand the use of TiCARos’ technology beyond autologous cell therapies. If the research collaboration yields positive results, Cartherics and TiCARos will negotiate a development and commercialization agreement for their CAR-NK therapeutic approach.

This collaboration between two leading companies in the field of cancer treatment has great potential to bring new treatments to market faster and more effectively than ever before.

By Samantha Jones

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